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Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes

โœ Scribed by Young Chul Kim; Sung Joon Kim; Jae Hoon Sim; Jae Yeoul Jun; Tong Mook Kang; Suk Hyo Suh; Insuk So; K. W. Kim

Publisher
Springer
Year
1998
Tongue
English
Weight
809 KB
Volume
436
Category
Article
ISSN
0031-6768

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In mammalian gastrointestinal myocytes, it is known that muscarinic stimulation activates nonselective cation channels through a G-protein and a Ca 2+dependent pathway. We recorded inward cationic currents following application of carbachol (Icch) to guinea-pig gastric myocytes, which were held at -