Protein Kinase C Does Not Mediate the Inhibitory Action of Lead on Vitamin D3-Dependent Production of Osteocalcin in Osteoblastic Bone Cells

Vitamin D receptor is not required for t

Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts

✍ Ramesh K. Wali; Juan Kong; Michael D. Sitrin; Marc Bissonnette; Yan Chun Li 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

## Abstract The rapid, non‐genomic actions of 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] have been well described, however, the role of the nuclear vitamin D receptor (VDR) in this pathway remains unclear. To address this question, we used VDR(+/+) and VDR(−/−) osteoblasts isolated from wild‐type