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Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

✍ Scribed by Doriano Fabbro; Romano Regazzi; Serban D. Costa; Christoph Borner; Urs Eppenberger

Book ID
115759778
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
467 KB
Volume
135
Category
Article
ISSN
0006-291X

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Modulation by staurosporine of phorbol-e
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✍ Tracey D. Bradshaw; Andreas Gescher; George R. Pettit πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 711 KB

I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine