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Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

✍ Scribed by House, C; Kemp, B.

Book ID
118155334
Publisher
American Association for the Advancement of Science
Year
1987
Tongue
English
Weight
817 KB
Volume
238
Category
Article
ISSN
0036-8075

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Regulatory domain of human protein kinas
Regulatory domain of human protein kinase Cα dominantly inhibits protein kinase Cβ-I regulated growth and morphology in Saccharomyces cerevisiae
✍ Amadeo M. Parissenti; Sandra A. Kim; Concettina M. Colantonio; Andrea L. Snihura 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 538 KB

This study demonstrates that the isolated regulatory (R) domain (amino acids 1 -270) of human protein kinase C a (PKCa) is a potent inhibitor of PKCP-I activity in a yeast expression system. The PKCa R domain fused to glutathione-S-transferase competitively inhibited the activity of yeast-expressed