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Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor

✍ Scribed by Jürgen Müllberg; Heidi Schooltink; Tanja Stoyan; Peter C. Heinrich; Stefan Rose-John


Book ID
115765719
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
545 KB
Volume
189
Category
Article
ISSN
0006-291X

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We investigated the regulatory mechanism of interleukin-6 (IL-6) synthesis induced by interleukin-1 (IL-1) in osteoblast-like MC3T3-E1 cells. IL-1 stimulated the secretion of IL-6 in a dose-dependent manner in the range between 0.1 and 100 ng/ml. Staurosporine and calphostin C, inhibitors of protein