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Protein kinase C activation inhibits cytokine-induced nitric oxide synthesis in vascular smooth muscle cells

✍ Scribed by Yong-jian Geng; Qi Wu; Göran K. Hansson


Book ID
116106126
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
793 KB
Volume
1223
Category
Article
ISSN
0167-4889

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Our previous studies showed that lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in cardiovascular tissues is attenuated by protein kinase C (PKC) inhibitors. In the current study, we identify a specific PKC isotype involved in the LPS signal transduction pathway that leads to NO format