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Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies

โœ Scribed by Alessia Pascale; Stefano Milano; Nerina Corsico; Laura Lucchi; Fiorenzo Battani; Edgardo Arrigoni Martelli; Marco Trabucchi; Stefano Govoni

Book ID
115889483
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
629 KB
Volume
265
Category
Article
ISSN
0014-2999

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โœ Dr. G. Forloni; N. Angeretti; S. Smiroldo ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 481 KB

The neuroprotective properties of acetyl-L-carnitine (ALCAR) were investigated in primary cell cultures from rat hippocampal formation and cerebral cortex of 17-day-old rat embryos. Chronic exposure to ALCAR (10-50 pM for 10 days) reduced the cell mortality induced by 24 hr fetal calf serum deprivat