Clozapine impairs insulin action by up-r
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Fabio Panariello; Giuseppe Perruolo; Angela Cassese; Ferdinando Giacco; Ginevra
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Article
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2012
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John Wiley and Sons
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English
โ 362 KB
Clinical and experimental evidence indicates that atypical antipsychotics impair glucose metabolism. We investigated whether clozapine may directly affect insulin action by analyzing insulin signaling in vitro and in vivo. Clozapine reduced insulin-stimulated glucose uptake in PC12 and in L6 cells,