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Protein kinase affinity reagents based on a 5-aminoindazole scaffold

✍ Scribed by Ratika Krishnamurty; Amanda M. Brock; Dustin J. Maly

Book ID: 104005028
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 475 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.069

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✦ Synopsis

Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures.

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