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Protein Interactions and Misfolding Analyzed by AFM Force Spectroscopy

✍ Scribed by Chad McAllister; Mikhail A. Karymov; Yoshiko Kawano; Alexander Y. Lushnikov; Andrew Mikheikin; Vladimir N. Uversky; Yuri L. Lyubchenko

Book ID
116662553
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
653 KB
Volume
354
Category
Article
ISSN
0022-2836

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Sample‐probe contact duration (dwell time) and loading force are two important parameters for the atomic force microscopy (AFM) force spectroscopy measurements of ligand–receptor interaction. A prolonged contact time may be required to initiate ligand–receptor binding as a result of slow on‐rate kin