A universal strategy for obtaining maximal protein expression or refolding remains elusive; however, headway has been made toward understanding these processes in vivo. The observation of reversible protein aggregation, asymmetry in protein--chaperone complexes, redox effects on disulfide formation,
Protein folding and spin glass
β Scribed by S.Suresh Rao; Somendra M. Bhattacharjee
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 421 KB
- Volume
- 224
- Category
- Article
- ISSN
- 0378-4371
No coin nor oath required. For personal study only.
β¦ Synopsis
We explicitly show the connection between the protein folding problem and spin glass transition. This is then used to identify appropriate quantities that are required to describe the transition. A possible way of observing the spin glass transition is proposed.
π SIMILAR VOLUMES
An important idea that emerges from the energy landscape theory of protein folding is that subtle global features of the protein landscape can profoundly affect the apparent mechanism of folding. The relationship between various characteristic temperatures in the phase diagrams and landmarks in the