✦ LIBER ✦
Protein fold recognition without Boltzmann statistics or explicit physical basis
✍ Scribed by Thomas Huber; Andrew E. Torda
- Book ID
- 105356506
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 1998
- Tongue
- English
- Weight
- 715 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0961-8368
No coin nor oath required. For personal study only.
✦ Synopsis
We present a fast method for finding optimal parameters for a low-resolution (threading) force field intended to distinguish correct from incorrect folds for a given protein sequence. In contrast to other methods, the parameterization uses information from >10(7) misfolded structures as well as a set of native sequence-structure pairs. In addition to testing the resulting force field's performance on the protein sequence threading problem, results are shown that characterize the number of parameters necessary for effective structure recognition.