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Protein flexibility and drug design: how to hit a moving target

✍ Scribed by Heather A Carlson

Book ID
104414681
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
180 KB
Volume
6
Category
Article
ISSN
1367-5931

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✦ Synopsis

The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.

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Disulfide crosslinks to probe the struct
Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein
✍ Lynne Regan; Arlene Rockwell; Zelda Wasserman; William Degrado πŸ“‚ Article πŸ“… 1994 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 980 KB

## Abstract The introduction of disulfide crosslinks is a generally useful method by which to identify regions of a protein that are close together in space. Here we describe the use of disulfide crosslinks to investigate the structure and flexibility of a family of designed 4‐helix bundle proteins