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Protein engineering: Hydrogen bonds in active sites

✍ Scribed by Galloway, John


Book ID
109738497
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
139 KB
Volume
314
Category
Article
ISSN
0028-0836

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Molecular dynamics simulation of the Michaelis complex, phospho-enzyme intermediate, and the wild-type and C12S mutant have been carried out to examine hydrogen-bonding interactions in the active site of the bovine low molecular weight protein-tyrosine phosphatase (BPTP). It was found that the S Ξ³ a