Unfolding dynamics of aβ-sheet protein s
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Eyles, Stephen J.; Dresch, Thomas; Gierasch, Lila M.; Kaltashov, Igor A.
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Article
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1999
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John Wiley and Sons
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English
⚖ 174 KB
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The unfolding dynamics of cellular retinoic acid-binding protein I (CRABP I), an 18 kDa predominantly b-sheet protein, were studied by monitoring the hydrogen-deuterium (H-D) exchange reaction under various solution conditions. A bimodal charge state distribution was observed when a denaturing agent