Protein-DNA recognition: new perspectives and underlying themes
✍ Scribed by von Hippel, P.
- Book ID
- 111912622
- Publisher
- American Association for the Advancement of Science
- Year
- 1994
- Tongue
- English
- Weight
- 541 KB
- Volume
- 263
- Category
- Article
- ISSN
- 0036-8075
No coin nor oath required. For personal study only.
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How DNA-binding proteins find their target sites remains a fascinating question. Early work on the Lac repressor showed that proteins specifically bind faster than simple diffusion allows. This led to the idea that recognition could be accelerated by combining diffusion with sliding along DNA and ho
How DNA-binding proteins find their target sites remains a fascinating question. Early work on the Lac repressor showed that proteins specifically bind faster than simple diffusion allows. This led to the idea that recognition could be accelerated by combining diffusion with sliding along DNA and ho
## Abstract The crystal structure of the four‐stranded DNA Holliday junction has now been determined in the presence and absence of junction binding proteins, with the extended open‐X form of the junction seen in all protein complexes, but the more compact stacked‐X structure observed in free DNA.