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Protein disulfide isomerase mutant lacking its isomerase activity accelerates protein folding in the cell

โœ Scribed by Toshiya Hayano; Mika Hirose; Masakazu Kikuchi

Book ID
115931734
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
783 KB
Volume
377
Category
Article
ISSN
0014-5793

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Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptide-binding activity
โœ Jeannette Winter; Stefan Gleiter; Peter Klappa; Hauke Lilie ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Cold Spring Harbor Laboratory Press ๐ŸŒ English โš– 715 KB

## Abstract Protein disulfide isomerase (PDI) supports proinsulin folding as chaperone and isomerase. Here, we focus on how the two PDI functions influence individual steps in the complex folding process of proinsulin. We generated a PDI mutant (PDIโ€abaโ€ฒc) where the **bโ€ฒ** domain was partially dele