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Membrane protein GARP is a receptor for

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

✍ Julie Stockis; Didier Colau; Pierre G. Coulie; Sophie Lucas 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

Human Treg and Th clones secrete the latent form of TGF-b, in which the mature TGF-b protein is bound to the latency-associated peptide (LAP), and is thereby prevented from binding to the TGF-b receptor. We previously showed that upon TCR stimulation, human Treg clones but not Th clones produce acti