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Protein adduction by reactive electrophiles and its consequences

✍ Scribed by D.C. Liebler


Book ID
116729356
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
69 KB
Volume
25
Category
Article
ISSN
0945-053X

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The enolates of cyclic ~-ketoesters react with electrophilic acetylenes to give the corresponding Michael adducts in good yields when the reaction is performed in acetone in the presence of catalytic amounts of K2CO 3. The Michael adducts resulting from ethynylmethylketone, when refluxed in toluene