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Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

✍ Scribed by John R. Babson; Nancy Sue Abell; Donald J. Reed


Book ID
115775539
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
703 KB
Volume
30
Category
Article
ISSN
0006-2952

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The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded