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Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria

✍ Scribed by P. K. Mehta; Gopal K. Khuller

Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
1008 KB
Volume
177
Category
Article
ISSN
0300-8584

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✦ Synopsis

Mannophosphoinositides isolated from mycobacterial cells were found to induce both humoral and cell-mediated immune responses in mice when injected as mannoside-methylated bovine serum albumin (MBSA) complexes. Immunization of mice with mannoside-MBSA complexes elicited significant protection against challenge with LDso dose of M. tuberculosis H37Rv as revealed by high survival rate, low values of root-specific lung weight, lung densities and colony forming units recovered from lung, liver and spleen, compared to the nonimmunized group. These observations were further substantiated by histopathological studies. The protective immunity elicited by mannoside-MBSA complexes against challenge with 3/. tuberculosis H37Rv was mediated by the cooperation of T-B ceils, as shown by the passive transfer of immune ceUs/sera' into syngeneic sublethally irradiated recipient mice.

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## Abstract Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP response‐regulator in __Mycobacterium tuberculosis__ results in a highly attenuated strain that demonstrates impressive protective eff