Protective effects ofN-Methyl-D-Aspartate receptor antagonism on VX-induced neuronal cell death in cultured rat cortical neurons

Spermine induces cell death in cultured

Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation

✍ Nuria de Vera; Emili Martínez; Coral Sanfeliu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 691 KB

## Abstract The polyamines putrescine, spermidine, and spermine play important roles in cell proliferation, differentiation, and modulation of ion channel receptors. However, the function of increased concentrations of these compounds in brain injury and disease is unclear, in that they have been p