Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
โ Scribed by E. Lele; F. Petak; F. Fontao; D. R. Morel; W. Habre
- Book ID
- 110908204
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 211 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0001-5172
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The effects of adenosine and some of its analogues on bronchoconstriction and mediator release were studied in isolated lungs of actively sensitized rats. The influence of two novel cardiotonic drugs, milrinone and sulmazole on these adenosine-induced effects was compared with that of theophylline,
SUMMARY: A ventilated perfused model of rat lung is described enabling continuous simultaneous measurement of pulmonary perfusion pressure (PPP), pulmonary inflation pressure (PIP) and lung weight. The preparation was stable for \(2 \mathrm{~h}\) before oedema formation commenced. Phenylephrine inje