Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model
β Scribed by SHEN, L.H.; YE, M.; DING, X.S.; HAN, Q.; ZHANG, C.; LIU, X.F.; HUANG, H.; WU, E.B.; HUANG, H.F.; GU, X.S.
- Book ID
- 119332919
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 816 KB
- Volume
- 223
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Although several studies have provided evidence for the therapeutic potential of bone marrowβderived mononuclear cells (MNCs) in animal models of stroke, the mechanisms underlying their benefits remain largely unknown. We have determined the neuroprotective potential of MNCs in primary
Treatment with bone marrow stromal cells (BMSCs) ameliorates neurological functional deficits after stroke. Nerve growth factor (NGF) is a neurotrophic factor that supports the survival and growth of neural cells. Noggin, an antagonist of bone morphogenetic protein (BMP), promotes the differentiatio