Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
✍ Scribed by Rade Injac; Martina Perse; Manica Cerne; Nejka Potocnik; Natasa Radic; Biljana Govedarica; Aleksandar Djordjevic; Anton Cerar; Borut Strukelj
- Book ID
- 104003756
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 1010 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0142-9612
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✦ Synopsis
The effects of fullerenol C 60 (OH) 24 (Frl) at doses of 25, 50, and 100 mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5 mg/kg/week for 3 weeks) chronic cardio-and hepato-toxicity and compared the effect with a well-known antioxidant, vitamin C (100 mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.