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Protective Effect of Stiripentol on Acetaminophen-Induced Hepatotoxicity in Rat

✍ Scribed by Agnès Tran; Jean-Marc Tréluyer; Elisabeth Rey; Jacques Barbet; Géraldine Ferracci; Philippe d'Athis; Jean Vincent; Gérard Pons

Book ID
112267283
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
349 KB
Volume
170
Category
Article
ISSN
0041-008X

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Cimetidine has been shown to protect against acetaminophen-mediated hepatotoxicity in both rats and mice. In contrast to cimetidine, ranitidine recently has been determined to potentiate the hepatotoxic action of acetaminophen in Fischer 344 rats. The present studies were designed to characterize th