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Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer

✍ Scribed by Ozkan Kanat; Turkkan Evrensel; Ibrahim Baran; Hakan Coskun; Mehmet Zarifoglu; Omer Faruk Turan; Ender Kurt; Mutlu Demiray; Guzin Gonullu; Osman Manavoglu

Book ID
111640926
Publisher
Springer US
Year
2003
Tongue
English
Weight
79 KB
Volume
20
Category
Article
ISSN
1357-0560

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Vorinostat increases carboplatin and pac
Vorinostat increases carboplatin and paclitaxel activity in non-small cell lung cancer cells
✍ Taofeek K. Owonikoko; Suresh S. Ramalingam; Beatriz Kanterewicz; Trent E. Balius πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 533 KB

## Abstract We observed a 53% response rate in non‐small cell lung cancer (NSCLC) patients treated with vorinostat plus paclitaxel/carboplatin in a Phase I trial. Studies were undertaken to investigate the mechanism (s) underlying this activity. Growth inhibition was assessed in NSCLC cells by MTT