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Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial

✍ Scribed by Paulo Renato Ferreira; James Freitas Fleck; Ada Diehl; Daniela Barletta; Aroldo Braga-Filho; Antonio Barletta; Ligia Ilha

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
115 KB
Volume
26
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

the study was designed to test whether vitamin E (VE) provides oral mucosal protection in patients with irradiated cancers of the head and neck.

Methods.

Fifty‐four patients with cancer of the oral cavity and oropharynx were randomly assigned to rinse the oral cavity in an oil solution containing either VE or placebo before every conventional fraction of 2 Gy and again 8 to 12 hours later during the 5 to 7 weeks of radiotherapy (RT).

Results.

Thirty‐six events/167 patient‐weeks (21.6%) and 54 events/161 patient‐weeks (33.5%) of symptomatic mucositis were observed in VE and placebo groups, respectively (p = .038). VE reduced the risk by 36%. Subjective data at the end of the treatment revealed that VE decreased pain grades 2 to 3 during RT (3 of 28 patients vs 14 of 26 patients, p = .0001). No significant influence was detected in survival.

Conclusion.

VE decreased the incidence of symptomatic oral radio‐induced mucositis in patients with cancer of the oropharynx and oral cavity. © 2004 Wiley Periodicals, Inc. Head Neck 26: XXX–XXX, 2004

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