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Protection of phosphate with the 9-fluorenylmethyl group. Synthesis of unsaturated-acyl phosphatidylinositol 4,5-bisphosphate

✍ Scribed by Yutaka Watanabe; Tomoko Nakamura; Hiroyuki Mitsumoto


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
177 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


Alkyl di-(9-fluorenylmethyl) phosphates obtained via phosphitylation were found to be suitable for protection of phosphoric monocsters, which were generated by treatment of the triesters with DBU or triethylamine. This strategy and a hydroxyl protecting group, 2-[2-(levulinoyloxy)ethyl]benzoyl were applied to synthesis of a dioleoyl analog of PI(4,5)P2.


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