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Protection, metalation, and electrophilic substitution of 5-methyl tetrazole

โœ Scribed by Bret E. Huff; Michael E. LeTourneau; Michael A. Staszak; Jeffrey A. Ward


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
215 KB
Volume
37
Category
Article
ISSN
0040-4039

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N-(2-Hydroxymethylphenyl)pyrrole was found to be amenable to selective a-metalation. Trapping with a variety of electrophilic reagents afforded the expected products with moderate to high yields. Derivatives formed by treatment of the organometahic intermediate with aldehydes, ketones or carbon diox