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Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure

✍ Scribed by Julian R. Haigh; Michael Adler; James P. Apland; Sharad S. Deshpande; Charles B. Barham; Patrick Desmond; Irwin Koplovitz; David E. Lenz; Richard K. Gordon

Book ID: 113518103
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 176 KB
Volume: 187
Category: Article
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2010.02.003

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Protection of human muscle acetylcholine

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## Abstract Introduction: Pretreatment with pyridostigmine bromide (PB) of human intercostal muscle fibers exposed to the irreversible acetylcholinesterase (AChE) inhibitor soman was investigated. Methods: Muscles were pretreated with 3 × 10^−6^ M PB or saline for 20 minutes, then exposed to 10^−7^