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Protection by paracetamol against various gastric irritants in the rat

✍ Scribed by A.A. Van Kolfschoten; P. Zandberg; L.P. Jager; J. Van Noordwijk

Book ID
113206053
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
430 KB
Volume
69
Category
Article
ISSN
0041-008X

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Reserpine (intraperitoneal, 5 mg/kg every day for 5 days) produced chronic ulceration of the rat stomach 2 weeks postdose. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30% of the rats, and this protection ex