Protection by dehydroepiandrosterone in mice infected with viral encephalitis
β Scribed by D. Ben-Nathan; B. Lachmi; S. Lustig; G. Feuerstein
- Publisher
- Springer Vienna
- Year
- 1991
- Tongue
- English
- Weight
- 713 KB
- Volume
- 120
- Category
- Article
- ISSN
- 1432-8798
No coin nor oath required. For personal study only.
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A significant protective effect of a native adrenal steroid, dehydroepiandrosterone (DHEA), was demonstrated in studies of two lethal viral infection models in mice: systemic coxsackievirus β¬34 and herpes simplex type 2 encephalitis. The steroid was active either by long-term feeding or by a single
Effector mechanisms responsible for resistance against ectromelia virus including antiviral activity of nonimmune macrophages, antiviral antibody, delayed footpad reaction to viral antigen, and interferon induction after viral infection were depressed in BALB/c mice bearing syngeneic Meth A tumor. T
## Abstract ## Background Japanese encephalitis (JE) is a serious infection and disease in southern and eastern Asia. The design and development of safer and more efficacious vaccines against Japanese encephalitis virus (JEV) is a highβpriority target in the world. Recently, baculovirus pseudotype