Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals

Glycine Protects Hepatocytes from Injury

Glycine Protects Hepatocytes from Injury Caused by Anoxia, Cold Ischemia and Mitochondrial Inhibitors, But Not Injury Caused by Calcium Ionophores or Oxidative Stress

✍ Diane C. Marsh; Paul K. Vreugdenhil; Vivian E. Mack; Folkert O. Belzer; James H. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 883 KB

Isolated hepatocykes, suspended in an organ preservation solution, can be preserved at 4" C for up to 6 days. After preservation, normothermic-normoxic incubation causes loss of hepatocyte viability. The addition of 3 mmol/L glycine to the rewarming medium prevents the loss of viability. In this stu