Protection against streptozotocin-induced diabetes by superoxide dismutase
โ Scribed by M. J. Robbins; R. A. Sharp; A. E. Slonim; I. M. Burr
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 346 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0012-186X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The protective effect of dimethyl urea, a hydroxyl radical scavenger, against low-dose streptozotocin-induced diabetes has been evaluated. Dimethyl urea was given to C57BL/KsJ mice before five daily injections of streptozotocin. The saline pre-treated control animals became gradually hyperglycaemic,
Superoxide dismutase (SOD, EC 1.15.1.1) was concentrated from mature-green tomato fruits by gel chromatography. The enzyme was inhibited by cyanide but not by chloroform-ethanol, and appears to contain zinc and lesser amounts of copper. SOD-activity levels were high in immature green fruits, decline
Experimental diabetes can be produced by agents with specific toxicity for pancreatic islet B cells. This effect has been reported to be modified both in vitro and in vivo by various radical scavengers including the enzyme superoxide dismutase. Copper(II)(3,5-diisopropylsalicylate)2 is lipophilic an