Protection against cytotoxic effects of arsenic by dietary supplementation with crude extract of Emblica officinalis fruit
✍ Scribed by Sonali Biswas; Geeta Talukder; Archana Sharma
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 50 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
Dietary administration of a crude aqueous extract of Emblica officinalis Gaertn. fruit reduced significantly the cytotoxic effects of sodium arsenite administered orally. The crude extract (685 mg/kg bw) was given daily by gavaging to age and sex matched laboratory bread Swiss albino mice for 7 and 14 days, followed by a single dose of sodium arsenite (2.5 mg/kg bw = 1/10 of LD 50 ). The animals were killed after 24 h and chromosome preparations made following a schedule of colchicine-fixative-air drying-Giemsa. The endpoints screened were chromosomal aberrations and damaged cells. The crude extract reduced arsenic damage bringing the cells almost to the normal level.