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Protection against acetaminophen-induced hepatotoxicity by L-CySSME and its N-acetyl and ethyl ester derivatives

✍ Scribed by Nagasawa, Herbert T. ;Shoeman, Don W. ;Cohen, Jonathan F. ;Rathbun, William B.


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
102 KB
Volume
11
Category
Article
ISSN
0887-2082

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## Abstract A series of double‐prodrugs of L‐cysteine, designed to release L‐cysteine in vivo and stimulate the biosynthesis of glutathione (GSH), were synthesized. To evaluate the hepatoprotective effectiveness of these double‐prodrugs, male Swiss‐Webster mice were administered acetaminophen (ACP)