Protective immunity afforded by attenuat
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Jonathan K. Nambiar; Rachel Pinto; Juan I. Aguilo; Kiyoshi Takatsu; Carlos Marti
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Article
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2011
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John Wiley and Sons
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English
β 364 KB
## Abstract Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP responseβregulator in __Mycobacterium tuberculosis__ results in a highly attenuated strain that demonstrates impressive protective eff