Proteasome Inhibitors Activate the Transcription Factors C/EBP-β and δ in Human Intestinal Epithelial Cells
✍ Scribed by Eric S Hungness; Bruce W Robb; Guang-ju Luo; Timothy A Pritts; Dan D Hershko; Per-Olof Hasselgren
- Book ID
- 115589210
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 114 KB
- Volume
- 290
- Category
- Article
- ISSN
- 0006-291X
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The transcription factors CCAAT/enhancer binding protein (C/EBP)- and -␦ are key regulators for the expression of the acute phase genes in the liver, such as complement component C3 and antichymotrypsin. In the brain, these acute phase proteins are produced in response to pro-inflammatory cytokines
## Abstract In recent studies, treatment with IL‐1β of cultured Caco‐2 cells, a human intestinal epithelial cell line, resulted in transcriptional upregulation of IL‐6 production. The role of C/EBP‐β and ‐δ in enterocyte IL‐6 production is not known. Stimulation with IL‐1β of Caco‐2 cells transient