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Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

✍ Scribed by Serdar Goktas; Yusuf Baran; Ali U. Ural; Sertac Yazici; Emin Aydur; Seref Basal; Ferit Avcu; Aysel Pekel; Bahar Dirican; Murat Beyzadeoglu

Book ID: 116951150
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 536 KB
Volume: 75
Category: Article
ISSN: 0090-4295
DOI: 10.1016/j.urology.2009.07.1215

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## BACKGROUND. Most prostate cancer cells respond to initial hormonal therapy; however, some of them eventually acquire resistance to the hormonal therapy. Hormone-independent prostate cancer usually exhibits resistance to chemotherapy and radiotherapy. Antioxidant systems are known to be involved