Proteasome inhibitor, bortezomib, for myeloma and lymphoma
โ Scribed by Kensei Tobinai
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 246 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1341-9625
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๐ SIMILAR VOLUMES
## Abstract The incidence of nonโHodgkin's lymphoma (NHL) has markedly increased in the US and other westernized countries in recent years and presents a considerable clinical challenge. NHL is divided into subtypes that follow an aggressive or indolent course. Follicular lymphoma (FL), the most co
## Abstract [D~2~](1__R__)โ3โmethylโ1โ[[(2S)โ1โoxoโ3โphenylโ2โ[(pyrazinylcarbonyl)amino]propyl]โamino]butyl] boronic acid ([D~2~]bortezomib), a proteasome inhibitor, was synthesized in 11 steps from __iso__butyryl chloride. Key steps in the synthesis included formation of the __iso__butyryl boronic
## Abstract ## Objective To explore the effect of bortezomib in splenocytes and fibroblastโlike synoviocytes (FLS) and its in vivo potency in a rat model of adjuvantโinduced arthritis (AIA), which resembles human rheumatoid arthritis (RA). ## Methods AIA was induced with Freund's complete adjuva