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Proteasome Inhibition Prevents Development of Experimental Dermal Fibrosis

✍ Scribed by Suleyman Serdar Koca; Metin Ozgen; Ferda Dagli; Mehmet Tuzcu; Ibrahim Hanifi Ozercan; Kazim Sahin; Ahmet Isik

Book ID
113066997
Publisher
Springer
Year
2011
Tongue
English
Weight
374 KB
Volume
35
Category
Article
ISSN
0360-3997

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Imatinib mesylate reduces production of
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
✍ JΓΆrg H. W. Distler; Astrid JΓΌngel; Lars C. Huber; Ursula Schulze-Horsel; Jochen πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 437 KB

Objective. Imatinib mesylate is a clinically welltolerated small molecule inhibitor that exerts selective, dual inhibition of the transforming growth factor ␀ (TGF␀) and platelet-derived growth factor (PDGF) pathways. This study was undertaken to test the potential use of imatinib mesylate as an ant