Proteasome Inhibition: a New Strategy in Cancer Treatment
β Scribed by Julian Adams; Vito J. Palombella; Peter J. Elliott
- Book ID
- 110234215
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 132 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## Abstract The incidence of nonβHodgkin's lymphoma (NHL) has markedly increased in the US and other westernized countries in recent years and presents a considerable clinical challenge. NHL is divided into subtypes that follow an aggressive or indolent course. Follicular lymphoma (FL), the most co
The ubiquitin-proteasome pathway plays a critical role in the degradation of cellular proteins and cell cycle control. Dysregulating the degradation of such proteins should have profound effects on tumor growth and causes cells to undergo apoptosis. The aims of this study are to evaluate the ubiquit