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Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor

✍ Scribed by Hiroshi Kido; Aiko Fukutomi; James Schilling; Yu Wang; Barbara Cordell; Nobuhiko Katunuma

Book ID: 115763666
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 386 KB
Volume: 167
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(90)92084-d

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The Kunitz-type protease inhibitor is one of the serine protease inhibitors. It is found in blood, saliva, and all tissues in mammals. Recently, a Kunitz-type sequence was found in the protein sequence of the amyloid beta precursor protein (beta APP). It is known that beta APP accumulates in the neu