✦ LIBER ✦

Protease inhibitors: A panacea?

✍ Scribed by Soghra Khatun Haq; Gulam Rabbani; Ejaz Ahmad; Sheikh Muhammad Atif; Rizwan Hasan Khan

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 95 KB
Volume: 24
Category: Article
ISSN: 1095-6670
DOI: 10.1002/jbt.20335

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

With the increasing evidence of protease involvement in several diseases, novel strategies for drug development involve the use of protease inhibitors (PIs). The local balance between protease inhibitors and proteases is an important determinant of the occurrence and progression of a particular disease. Hence, enzymes and their cognate inhibitors are finding their applications as diagnostic and prognostic markers. PIs are widely implicated for their use in host defense against infection, tissue repair and matrix production, blood coagulation, cancer, and they are, therefore, the current focus as therapeutic alternatives for major diseases such as AIDS and Alzheimer's diseases. This review is a brief summary of the varied role of protein protease inhibitors in controlling the activity of aberrant enzymes in several diseases afflicting mankind today. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:270–277, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20335

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