✦ LIBER ✦
Protease-catalysed synthesis of Z-l-aminoacyl-l-caprolactam amides from Z-protected amino acid esters and dl-α-amino-ε-caprolactam
✍ Scribed by Alexander Lang; Peter Kuhl
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 154 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The enzymatic synthesis of Z-L-aminoacyl-L-caprolactam amides from Z-protected amino acid esters and DL-a-amino-e-caprolactam (ACL) was accomplished by the thiol proteases papain, bromelain and ficin in aqueous-organic media. Product yields of 96% and 87% for Z-Gly-