Protamine sulphate is an effective inhibitor of heparin and is used clinically to neutralise both low molecular weight heparins (LMWH) and unfractionated heparin (UFH). However, protamine sulphate does not fully counter the anti-Xa effect of LMWH, even in excess (>40 ฮผg to 1 IU/ml). To investigate t
Protamine neutralisation of low molecular weight heparins and their oligosaccharide components
โ Scribed by Mette Schroeder; John Hogwood; Elaine Gray; Barbara Mulloy; Anne-Marie Hackett; Kristian B. Johansen
- Book ID
- 105893722
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 259 KB
- Volume
- 399
- Category
- Article
- ISSN
- 1618-2650
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๐ SIMILAR VOLUMES
A polycation-sensitive membrane electrode based on the ion-exchanger dinonylnaphthalene sulfonate has previously been developed and used as an endpoint detector for the determination of unfractionated heparin in whole blood samples via simple potentiometric titration with protamine. Herein, we repor
The application of capillary electrophoresis to total compositional analysis of heparin and low-molecularweight heparin samples has been studied. Optimum resolution of 17 defined oligosaccharides was obtained with the buffer system composed of \(10 \mathrm{~mm}\) sodium borate and \(50 \mathrm{~mm}\