Prostate-specific antigen (PSA) increases in the plasma of patients with prostate cancer, and has therefore been used as a reliable tumor marker. It has been demonstrated that prostate cancer cells over-express urokinase-type plasminogen activator @PA), which plays an important role in tumor invasio
โฆ LIBER โฆ
Prostatic kallikrein hK2, but not prostate-specific antigen (hK3), activates single-chain urokinase-type plasminogen activator
โ Scribed by Gilles Frenette; Roland R. Tremblay; Claude Lazure; Jean Y. Dube
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 43 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0020-7136
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Human kallikrein 2 (hK2) is a secreted, trypsin-like protease that shares 80% amino acid sequence identity with prostate-specific antigen (PSA). hK2 has been shown to be a serum marker for prostate cancer and may also play a role in cancer progression and metastasis. We have previously identified a