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Prostatic intraepithelial neoplasia and prostate-specific antigen

โœ Scribed by J. R. Porter; M. K. Brawer

Book ID
104655071
Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
543 KB
Volume
11
Category
Article
ISSN
0724-4983

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โœฆ Synopsis

Prostatic intraepithelial neoplasia (PIN) is a putative premalignant lesion of the prostate gland. PIN has been demonstrated to share morphologic and phenotypic similarities to invasive carcinoma of the prostate. In addition, PIN is spatially related to invasive carcinoma and occurs with greater frequency in men whose prostates harbor carcinoma. Prostate-specific antigen (PSA) is a glycoprotein produced by the prostatic epithelium. For PSA to be detected in the serum, it must traverse several tissue layers to reach the circulatory system. PSA levels associated with PIN are intermediate between those of benign and malignant prostate tissue. Spatially associated occult carcinoma, disruption of the basal cell layer, and increased vascularity may account for elevated PSA values in PIN.

๐Ÿ“œ SIMILAR VOLUMES

Prostate specific membrane antigen expre
Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma : A study of 184 cases
โœ David G. Bostwick; Anna Pacelli; Michael Blute; Patrick Roche; Gerald P. Murphy ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 272 KB ๐Ÿ‘ 1 views

## BACKGROUND. Prostate specific membrane antigen (PSM) is a membrane-bound antigen that is highly specific for benign and malignant prostate epithelial cells. Its expression in high grade prostatic intraepithelial neoplasia (PIN) has not been compared with that in prostate carcinoma. ## METHODS.