✦ LIBER ✦

Prostatic cell lineage markers: Emergence of BCL2+ cells of human prostate cancer xenograft LuCaP 23 following castration

✍ Scribed by Alvin Y. Liu; Eva Corey; Franck Bladou; Paul H. Lange; Robert L. Vessella

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 572 KB
Volume: 65
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960103)65:1<85::aid-ijc15>3.0.co;2-h

No coin nor oath required. For personal study only.

✦ Synopsis

A model of prostate cancer progression based on the expression pattern of informative genes in the human prostate cancer xenograft LuCaP 23.1 is presented. Apparently, there are at least 2 tumor cell populations of LuCaP 23.1, representing 2 different phenotypes. One is NSE (neuron-specific enolase)positive and the other NSE-negative. NSE-positive tumors were recovered after hormone-independent growth in castrated mice. These hormone-independent tumors also expressed BCU, a gene product shown to inhibit apoptosis. With NSE, BCL2 and PSA (prostate-specific antigen) as identifying markers, the model specifies a putative progression sequence of the prostate cancer cell types. We also show a proposed lineage relationship among the 3 principal normal cell types found in the prostatic epithelium.

📜 SIMILAR VOLUMES

A recombinant defective adenoviral agent

A recombinant defective adenoviral agent expressing anti-bcl-2 ribozyme promotes apoptosis of bcl-2-expressing human prostate cancer cells

✍ Thambi Dorai; Harris Perlman; Kenneth Walsh; Ahmad Shabsigh; Erik T. Goluboff; C 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB 👁 1 views

Over-expression of bcl-2, a potent anti-apoptosis protein, is likely to be one of the genetic mechanisms through which human prostate cancer cells develop resistance to hormonal and other forms of therapy. To develop a therapeutic agent for hormone-resistant prostate cancer based on suppression of b

bcl-2 over-expression delays radiation-i

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

✍ Natasha Kyprianou; Edward D. King; David Bradbury; Juong G. Rhee 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 394 KB 👁 2 views

In this study we evaluated the effect of over-expression of the bcl-2 gene, a potent apoptosis suppressor, on radiationinduced apoptotic cell death in 2 human prostate cancer cell lines, androgen-independent PC-3 cells and androgen-sensitive LNCaP cells. Cells were transfected with the bcl-2 gene an

Establishing human prostate cancer cell

Establishing human prostate cancer cell xenografts in bone: Induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines

✍ Tony T. Wu; Robert A. Sikes; Quanjun Cui; George N. Thalmann; Chinghai Kao; Cher 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 497 KB 👁 2 views

LNCaP lineage-derived human prostate cancer cell lines C4-2 and C4-2B 4 acquire androgen independence and osseous metastatic potential in vivo. Using C4-2 and C4-2B 4 the goals of the current investigation were 1) to establish an ideal bone xenograft model for prostate cancer cells in intact athymic

Expression of gangliosides, GD1a, and si

Expression of gangliosides, GD1a, and sialyl paragloboside is regulated by NF-κB-dependent transcriptional control of α2,3-sialyltransferase I, II, and VI in human castration-resistant prostate cancer cells

✍ Koji Hatano; Yasuhide Miyamoto; Norio Nonomura; Yasufumi Kaneda 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 666 KB

## Abstract Gangliosides are sialic acid–containing glycosphingolipids that are associated with tumor malignancy and progression. Among the enzymes required for the production of gangliosides, sialyltransferases have received much attention in terms of their relationship with cancer. In our previou